Dipanjan Pan

Dipanjan Pan
Dipanjan Pan

Dipanjan Pan

Assistant Professor
Materials Science and Engineering
  • Bioengineering
3213 Digital Computer Lab MC 278
1304 W. Springfield
Urbana Illinois 61801
(217) 244-2938

Biography

Dipanjan Pan, PhD is a doctorate in Chemistry and a Fellow of Royal Society of Chemistry with extensive experience in nanotechnology, materials science molecular imaging and drug delivery from academia (Washington University, UIUC) and industry sectors (GE). He is presently an Assistant Professor in Bioengineering, Materials Science and Engineering and Institute of Sustainability in Energy and Environment in University of Illinois, Urbana-Champaign. He also holds a full-time faculty position with Beckman Institute for Advanced Science and Technology and University of Illinois Cancer Center. He directs the Masters in Engineering Program in Bioinstrumentation in the College of Engineering. Earlier he was an Assistant Professor in Medicine, Research in Washington University School of Medicine, St Louis. His laboratories are located at the Biomedical Research Center in Carle Foundation Hospital and Beckman Institute. His research is highly collaborative and interdisciplinary centering on the development of novel materials for biomedical applications through in silico-to-in vivo research. His multidisciplinary approaches encompass a variety of chemical, polymeric, molecular biological and analytical methods to address issues related to cardiovascular and cancer diseases. He has authored over 90 original publications, 2 edited books (Taylor Francis and Springer), numerous abstracts, and patents in the area of materials science and nanomedicine. He received his PhD from the Indian Institute of Technology, Kharagpur, India in 2002 and pursued a postdoctoral career in polymer science and technology at the Department of Chemistry, Washington University in St. Louis. In 2005, he joined General Electric and worked as a part of the global research team supporting the development of their biosciences initiatives. Dr. Pan joined the WU faculty in 2007. Subsequently, he co-invented several nanoparticle platforms for molecular imaging application with CT, MRI, optical and photoacoustic imaging. His research is funded externally by the NIH, NSF, American Heart Association, Michael Reese Foundation, Children's Discovery Institute and other external funding organizations. He is the founder for three University-based start-ups- Vitruvian Biotech, InnSight Technology, Inc. and Kalocyte, Inc. Presently he has two ongoing clinical trials in collaboration with Carle Foundation hospital. He serves in the study section review board for NIH (National Cancer Institute) and American Heart Association (Innovative Research Grant). He is an editor for Scientific Reports (Nature Publishing) within Chemical Biology theme and also serves as a member of Editorial Advisory board of Molecular Pharmaceutics (ACS).

Academic and Scientific Experience

Education

  • Postdoctoral Research, Department of Chemistry, Washington University in St Louis, USA (With Professor Karen L. Wooley)
  • Ph.D., Indian Institute of Technology (IIT), KGP, India, Synthetic Chemistry, 2002
  • M.S., Vidyasagar University, India, Chemistry, 1997
  • B.S., Vidyasagar University, India, Chemistry, 1995

Academic Positions

  • Associate Professor, Department of Bioengineering, UIUC, 2017-present
  • Assistant Professor, Department of Bioengineering, UIUC, 2013-2017
  • Assistant Professor, Affiliate, Institute for Sustainability, Energy, and Environment, UIUC, 2015-present
  • Assistant Professor, Full-time faculty, Beckman Institute, Bio-imaging Science and Technology Group, UIUC, 2014-present
  • Assistant Professor, Affiliate, Department of Materials Science and Engineering, UIUC, 2014-present
  • Assistant Professor, Part-time faculty, Beckman Institute, Bio-imaging Science and Technology Group, UIUC, 2013-2014
  • Assistant Professor, Research Affiliate, Carle Foundation Hospital and Mills Breast Cancer Institute, 2013-present
  • Assistant Professor in Medicine, Research, Division of Cardiology, Washington University in St. Louis, Sch of Med, USA, 2010-2013
  • Instructor in Medicine, Research, Division of Cardiology, Washington University in St Louis, Sch of Med, USA, 2007-2010
  • Intellectual Property analyst, General Electric (GE) Global Research, 2005-2006

Other Professional Employment

  • Research Affiliate, Mills Breast Cancer Institute, Carle Foundation Hospital, 08/2013-
  • Research Member, University of Illinois, Chicago Cancer Center, 07/2014-

Major Consulting Activities

  • Co-Founder, Chief Technology Officer, KaloCyte, Inc. 2016-
  • Co-Founder, Vice President, Chief Technology Officer, InnSight Tech, Inc. 2014-
  • Founder President, CEO, VitruVian Biotech, 2013-
  • Academic Editor, Accdon, LLC 2010-

Courses Taught

  • BIOE 198 - Nanotechnology:Risks & Promise
  • BIOE 201 - Conservation Principles Bioeng
  • BIOE 298 - Nanotechnology:Risks & Promise
  • BIOE 497 - Individual Study
  • BIOE 498 - Imaging & Therapeutic Agents
  • BIOE 570 - Bioinstrumentation Seminar
  • BIOE 570 - Seminar Series
  • BIOE 571 - Biological Measurement I
  • BIOE 572 - Biological Measurement II
  • BIOE 575 - Bioinstrumentation Project
  • BIOE 575 - Capstone Project
  • BIOE 598 - Imaging & Therapeutic Agents

Journal Editorships

  • Guest editor, Special thematic issue on "Theranostic Nanomedicine with Functional Nano-architechture" for Molecular Pharmaceutics (ACS) 2012
  • Volume editor, “Topic in Medicinal Chemistry”, Springer, 2013-
  • Guest editor, Special issue on CT imaging for Contrast Media and Molecular Imaging (Wiley) 2014
  • Guest editor, Special issue on ‘Gene Delivery’ for Molecular Pharmaceutics (ACS) 2014
  • Editorial Board, Molecular Pharmaceutics (American Chemical Society) 2014-

Research Statement

Personalized Nanomedicine-Converging basic science and engineering with medicine: At the laboratory for materials in medicine (MatMed) we are striving to make nanomedicine patient specific by following a nano 'Omics' based approach. Our research is broadly aimed at the understanding and creating defined materials for molecular imaging, drug delivery and non-viral gene delivery applications with a focus on structure, function and engineering processes. The philosophy of my research program is that integrated solutions to problems can be formulated by in silico-to-in vivo approach and synergistic developments in four major areas: computational and experimental drug discovery (e.g. stem like cancer cells and transcription factors), molecularly specific contrast probes and their applications in preclinical and clinical models and nanotoxicity assessment. In close collaboration with clinical scientists we integrate basic science and engineering with medicine. The major thrust of this research is to create defined nano-architectures for molecular imaging, drug delivery and non viral gene delivery applications with a focus on structure, function and engineering processes. Our multidisciplinary approaches encompass a variety of chemical, polymeric, molecular biological and analytical methods to address issues related to cardiovascular and cancer diseases. Enquires include detection of molecular changes responsible for disease pathogenesis (cardiovascular, inflammatory, and cancer) and site-specific delivery of therapeutic agents (chemotherapeutic, thrombolytic, and siRNA/RNAi) with biochemically triggered release mechanisms.

Research Interests

  • Nano 'Omics'
  • Translational Nanomedicine
  • Molecular Imaging
  • Stem Cell Therapy, Combinatorial Therapeutics and Drug Delivery
  • Bioengineering Sustainability
  • In Silico to In Vivo
  • Drug Discovery and Repurposing

Books Edited or Co-Edited (Original Editions)

Chapters in Books

  • Pan D. Personalized Medicine: Where do we go from here?. Top Med Chem 2015. DOI: 10.1007/7355_2015_95 Springer (Edited By: Pan, Dipanjan)
  • Caffarini J, Kelleher N, Konopka CC, Mazurek M, Nandyala A, Patel D, Slania S, Wang S, Yada RC, Pan D. Multimodal Imaging and Theranostic Application of Disease-directed Agents. Top Med Chem 2015. 1-29. Springer (Edited By: Pan, Dipanjan)
  • Daza EA, Goatz D, Frankowski D, Imgruet M, Kus J, Lake R, Modak M, Olsen N, Ostadhossein FY, Schwartz-Duval A, Wade D, Zimmer A, Kolmodin N, Pan D. Nano-enabled Delivery of Intracellular Therapeutics. Top Med Chem 2015. Springer (Edited By: Pan, Dipanjan)
  • Chang H, Braswell S, George J, Gryka M, Kim S, Kolmodin N, Kumar M, Seadler B, Sonoiki O, Pan D*. Barriers in Nanomedicine: The Importance of Defined Chemistry and Engineering Approaches for Clinical Translation. Top Med Chem 2015. DOI: 10.1007/7355_2014_68 Springer (Edited By: Pan, Dipanjan)
  • Pan D: Nanomedicine: perspective and promises From Nanomedicine (2015), 151-159. (Edited By: Pan, Dipanjan)
  • Pan D, Misra SK, Kim S: Contrast agents for computed tomographic imaging From Nanomedicine (2015), 131-149. (Edited By: Pan, Dipanjan)
  • Pan D: Nanomedicine: Introduction From Nanomedicine (2015), 151-159. (Edited By: Pan, Dipanjan)
  • Lanza, GM, Caruthers SD, Schmieder, AH, Pan D, Hu G, Zhang H, Senpan A, Allen, JS Williams, T Scott, MJ, Wickline, SA Washington University, WA, USA. pp. 87-118 (Chapter 5). Perfluorocarbon Nanoparticles: A Theranostic Technology for MR Imaging Nanotechnology in Modern Medical Imaging and Interventions 2014 Nova Science Publishers (Editors: Xiaoming Yang (Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA)
  • Pan D: Frontiers in Nanobiomedical Research: Handbook of Nanobiomedical ResearchFundamentals, Applications and Recent Developments (In 4 Volumes) Volume 3: Applications in Diagnostics, Metal Nanoparticles for Photoacoustic Imaging (Dipanjan Pan) ISBN: 978-981-4520-64-5; October 2014.
  • Pan D, Lanza GM: Recent advances in contrast agents for magnetic resonance imaging. CMR Book Chapter 2012 Textbook of CMR-2nd Edition-Schattauer-Publishers.

Monographs

  • Chang H, Braswell S, George J, Gryka M, Kim S, Kolmodin N, Kumar M, Seadler B, Sonoiki O, Pan D*. Barriers in Nanomedicine: The Importance of Defined Chemistry and Engineering Approaches for Clinical Translation. Top Med Chem 2015. DOI: 10.1007/7355_2014_68 (Invited review)
  • Dobrucki LW, Pan D, Smith AM: Multiscale Imaging of Nanoparticle Drug Delivery. Curr Drug Targets. 2015, 16(6):560-70. (Invited review)
  • Lanza GM, Marsh JN, Hu G, Scott M, Schmieder AH, Caruthers SD, Pan D, Wickline SA: Rationale for a Nanomedicine Approach to Thrombolytic Therapy, Stroke 2010, S42-S44.
  • Lanza GM, Pan D*. Molecular imaging with computed tomography. Contrast Media Mol Imaging. 2014 Jan-Feb; 9(1):1-2. (Invited co-guest editor)
  • Ostadhossein F, Pan D* Functional Carbon Nanoparticle for Multiscale Imaging. Nanomedicine and Nanobiotechnology Interdisciplinary Reviews (WIRE) 2016 (Invited Review)
  • Pan D* "Theranostic Nanomedicine with Functional Nanoarchitechture" Special thematic issue for Molecular Pharmaceutics 2013; 10(3):781-2. (Invited guest editor)
  • Pan D* Nephrogenic Systemic Fibrosis (NSF): What It Really Means for Materials Scientists? J Biotechnol Biomaterial 2012, 2, e109.
  • Pan D*, Caruthers SD, Chen J, Winter PM, Senpan A, Schmieder AH, Wickline SA, Lanza GM: Nanomedicine strategies for molecular targets with MR and optical imaging. Future Med. Chem. March 2010, 2(3), 471-490. (Invited review)
  • Pan D*, Caruthers SD, Senpan A, Schmieder AH, Wickline SA, Lanza GM: Revisiting an old friend: manganese-based MRI contrast agents. Nanomedicine and Nanobiotechnology, 2011, 3(2), 162-173.
  • Pan D*, Caruthers SD, Wickline SA, Lanza GM: Nanomedicine: Perspective and promises with ligand-directed molecular imaging. European J. Rodiology, 2009, 70, 274-285.
  • Pan D*, Kim B, Wang LH, Lanza GM. A Brief Account of Nanoparticle Contrast Agents for Photoacoustic Imaging. Nanomedicine and Nanobiotechnology (WIRE), 2013, 5(6):517-43.
  • Pan D*, Pramanik M, Wickline SA, Wang LH, Lanza GM: Recent Advances in Colloidal Gold Nanobeacons for Molecular Photoacoustic Imaging. Contrast Media and Molecular Imaging 2011, 6 378-388.
  • Pan D*, Schirra CO, Wickline SA, Lanza GM. Multicolor Computed Tomographic Molecular Imaging with Non-crystalline High Metal Density Nanobeacons: Contrast Media and Molecular Imaging 2014; 9(1):13-25.
  • Pan D*, Schmieder A, Wickline SA, Lanza GM: Manganese-based MRI contrast agents: past, present and futures. Tetrahedron 2011, 67(44), 8431-8444.
  • Pan D*. Next generation gene delivery approaches: recent progress and hurdles. Mol Pharm. 2015 Feb 2; 12(2):299-300. (Invited guest editor)

Selected Articles in Journals

  • Misra SK, Ostadhossein F, Daza E, Johnson EV, Pan D*. You have full text access to this contentHyperspectral Imaging Offers Visual and Quantitative Evidence of Drug Release from Zwitterionic-Phospholipid-Nanocarbon When Concurrently Tracked in 3D Intracellular Space. Advanced Functional Materials 2016. DOI: 10.1002/adfm.201602966
  • Schwartz-Duval A, Misra SK, Mukherjee PM, Ostadhossein A., Gryka MC, Tiwari S, Bhargava R, Pan D*. An anisotropic propagation technique for synthesizing hyperbranched polyvillic gold nanoparticles. Nano Research 2016 doi:10.1007/s12274-016-1174-y
  • Daza EA, Misra SK, Schwartz-Duval AS, Ohoka A, Miller C, Pan D*. Nano-Cesium for Anti-Cancer Properties: An Investigation into Cesium Induced Metabolic Interference. ACS Appl Mater Interfaces. 2016 Sep 23. [Epub ahead of print]
  • Ostadhossein F, Misra SK, Mukherjee P, Ostadhossein A, Daza E, Tiwari S, Mittal S, Gryka MC, Bhargava R, Pan D*. Defined Host-Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer. Small. 2016 Aug 22. doi: 10.1002/smll.201601161. [Epub ahead of print]
  • Misra SK, Mukherjee P, Chang HH, Tiwari S, Gryka M, Bhargava R, Pan D*. Multi-functionality Redefined with Colloidal Carotene Carbon Nanoparticles for Synchronized Chemical Imaging, Enriched Cellular Uptake and Therapy. Sci Rep. 2016 Jul 11;6:29299.
  • Misra SK, Ye M, Ostadhossein F, Pan D*. Pro-haloacetate Nanoparticles for Efficient Cancer Therapy via Pyruvate Dehydrogenase Kinase Modulation. Sci Rep. 2016 Jun 21;6:28196.
  • Vulugundam G, Misra SK, Ostadhossein F, Schwartz-Duval AS, Daza EA, Pan D*. (-)/(+)-Sparteine induced chirally-active carbon nanoparticles for enantioselective separation of racemic mixtures. Chem Commun (Camb). 2016 Jun 14;52(47):7513-6.
  • Misra SK, Ohoka A, Ostadhossein FY, Kim B, Ray PS, Pan D*, Carotenoid Nanovector for Efficient Therapeutic Gene Knockdown of Transcription Factor FOXC1 in Liver Cancer. Bioconjug Chem. 2016, 27(3):594-603.
  • Misra SK, Mukherjee PM, Swartz-Duval A, Ohoka A, Gryka MC, Tiwari S, Bhargava R, Pan D*, Vibrational spectroscopy and imaging for concurrent cellular trafficking of co-localized doxorubicin and deuterated phospholipid vesicles. Nanoscale 2015 (Advanced Article)
  • Gartia MR, Misra SK, Ye M, Schwartz-Duval A, Plucinski L, Zhou X, Kellner D, Labriola LT, Pan D*, Point-of-service, quantitative analysis of ascorbic acid in Aqueous humor for evaluating anterior globe integrity. 2015 Scientific Report, 2015, 5:16011.
  • Misra SK, Chang H, Mukherjee P, Tiwari S, Ohoka A, Pan D*. Regulating Biocompatibility of Carbon Spheres via Defined Nanoscale Chemistry and a Careful Selection of Surface Functionalities. Scientific Report, 2015, 5:14986.
  • Misra SK, Ghoshal G, Gartia M, Wu Z, Ye Mao, Bromfield CR, Williams EM, Tangella KV, Schulten K, Ray PS, Burdette EC, Pan D*. Trimodal Therapy: Combining Hyperthermia with Repurposed Bexarotene and Ultrasound for Treating Liver Cancer. ACS Nano, 2015, 9(11):10695-718.
  • Misra SK, Graff RW, Srivastava I, Wang X, Ohoka A, Kampert TL, Gao H*, Pan D*. Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles. Chemical Communications, 2015, 51(93):16710-3.
  • Misra SK, Ghoshal G, Ray PS, Burdette EC, Pan D*. Bi-modal Cancer Treatment Utilizing Therapeutic Ultrasound and Engineered Therapeutic Nanobubble. RSC Adv., 2015, 5, 63839-63845.
  • Pan D*. Personalized Medicine: Where do we go from here?. Top Med Chem 2015. DOI 10.1007/7355_2015_95 (Invited review)
  • Daza EA, Goatz D, Frankowski D, Imgruet M, Kus J, Lake R, Modak M, Olsen N, Ostadhossein FY, Schwartz-Duval A, Wade D, Zimmer A, Kolmodin N, Pan D*. Nano-enabled Delivery of Intracellular Therapeutics. Top Med Chem 2015. In Press (Invited review)
  • Caffarini J, Kelleher N, Konopka CC, Mazurek M, Nandyala A, Patel D, Slania S, Wang S, Yada RC, Pan D*. Multimodal Imaging and Theranostic Application of Disease-directed Agents. Top Med Chem 2015. 1-29. DOI 10.1007/7355_2015_91 (Invited review)
  • Misra SK, Ye M, Kim S, Pan D*. Defined Nanoscale Chemistry Influences Delivery of Peptido-Toxins for Cancer Therapy. PLoS One. 2015 Jun 1;10(6):e0125908.
  • Mukherjee P, Misra SK, Gryka MC, Chang HH, Tiwari S, Wilson WL, Scott JW, Bhargava R*, Pan D*. Tunable Luminescent Carbon Nanospheres with Well-Defined Nanoscale Chemistry for Synchronized Imaging and Therapy. Small 2015, 11 (36), 4691-4703. (Cover Article) Cover Link: http://onlinelibrary.wiley.com/doi/10.1002/smll.201570224/full
  • Misra SK, Jensen TW, Pan D*. Enriched inhibition of cancer and stem-like cancer cells via STAT-3 modulating niclocelles. Nanoscale. 2015 7(16):7127-32. (Cover Article) Cover Link: http://pubs.rsc.org/en/content/articlelanding/2015/nr/c5nr90079d#!divAbstract (Nanoscale, 7, 6862-6862)
  • Dobrucki LW, Pan D, Smith AM: Multiscale Imaging of Nanoparticle Drug Delivery. Curr Drug Targets. 2015, 16(6):560-70. (Invited review)
  • Chang H, Braswell S, George J, Gryka M, Kim S, Kolmodin N, Kumar M, Seadler B, Sonoiki O, Pan D*. Barriers in Nanomedicine: The Importance of Defined Chemistry and Engineering Approaches for Clinical Translation. Top Med Chem 2015. DOI: 10.1007/7355_2014_68 (Invited review)
  • Pan D*, Schirra CO, Wickline SA, Lanza GM. Multicolor Computed Tomographic Molecular Imaging with Non-crystalline High Metal Density Nanobeacons: Contrast Media and Molecular Imaging 2014; 9(1):13-25. (Invited review)
  • Pan D*. Next generation gene delivery approaches: recent progress and hurdles. Mol Pharm. 2015 Feb 2; 12(2):299-300. (Invited guest editor) (Cover Article) Cover Link: http://pubs.acs.org/toc/mpohbp/12/2
  • Lanza GM, Pan D*. Molecular imaging with computed tomography. Contrast Media Mol Imaging. 2014 Jan-Feb; 9(1):1-2. (Invited co-guest editor)
  • Wang K, Pan D, Schmieder AH, Senpan A, Hourcade DE, Pham CT, Mitchel LM, Caruthers SD, Cui G, Wickline SA, Shen B, Lanza GM. Synergy Between Surface and Core Entrapped Metals in a Mixed Manganese-Gadolinium Nanocolloid Affords Safer MR Imaging of Sparse Biomarkers. Nanomedicine. 2015, S1549-9634(15), 00015-5.
  • Wang K, Pan D, Schmieder AH, Senpan A, Caruthers SD, Cui G, Allen JS, Zhang H, Shen B, Lanza GM. Atherosclerotic Neovasculature MR Imaging with Mixed Manganese-Gadolinium Nanocolloids in Hyperlipidemic Rabbits. Nanomedicine. 2015, S1549-9634(15), 00014-3.
  • Misra SK, Ohoka A, Kolmodin NJ, Pan D*. Next generation carbon nanoparticles for efficient gene therapy. Molecular Pharmaceutics 2015 Feb 2;12(2):375-85.
  • [Soodgupta D, Pan D,] Cui, Senpan A, Yang X., Lu L, Weilbaecher, KN, Prochownik EV, Lanza GM, Tommasson, MH. Small molecule MYC inhibitor conjugated to integrin-targeted nanoparticles extends survival in a mouse model of disseminated multiple myeloma. Mol Cancer Ther. 2015, 14(6):1286-94. [Authors of Equal Contribution]
  • Pan D*, Kim B, Soodgupta D, Senpan A, Yang X, Schmieder AH, Sanyal N, Wickline SA, Tomasson M, Lanza GM: Combating Melanoma using Nanotherapy and Sn-2 Phospholipase-labile Myc-Max Antagonist Prodrug. Nanomedicine (UK), 2015 10(2): 241-51.
  • [Zhang R, Pan D,] Cai X, Yang X, Senpan A, Allen JS, Lanza GM, Wang LV. ανβ3-targeted Copper Nanoparticles Incorporating an Sn2 Lipase-Labile Fumagillin Prodrug for Photoacoustic Neovascular Imaging and Treatment. Theranostics. 2015 Jan 1; 5(2):124-33. [Authors of Equal Contribution]
  • Misra SK, Kim B, Lanza GM, Pan D*: Synthesis of a Sensitive ‘Pincer’ Scavenger for Direct, Quantitative Assessment of Metals in Serum from Patients with Liver Disease. Colloids Surf B Biointerfaces. 2015, S0927-7765(14)00735-8.
  • Misra SK, Ye M, Kim S, Pan D*. Highly Efficient Anti-Cancer Therapy using Well-defined Polymeric Nanoparticle and Scorpion ‘NanoVenin’. Chemical Communications 2014 50(87):13220-3. (Cover Article) Cover Link: Chem. Commun., 2014,50, 13164-13164. DOI: 10.1039/C4CC90413C
  • Misra SK, Kus J, Kim S, Pan D*, Nanoscopic Poly-DNA-Cleaver for Breast Cancer Regression with Induced Oxidative Damage. Molecular Pharmaceutics 2014 11(11):4218-27.
  • Misra SK, Kim B, Chang, HH, Pan D*, Defying Symmetry: A 'flowery' Architecture with Augmented Surface Area from Gold Coated Polymeric ‘NanoBlooms’ RSC Advances 4, 34303-34306, 2014.
  • Pham CT, Thomas DG, Mitchell LM, Huang JL, Senpan A, Hu G, Gordon M, Baker NA, Pan D, Lanza GM, Hourcade DE: Application of a hemolysis assay for analysis of complement activation by perfluorocarbon nanoparticles. Nanomedicine. 2014 Apr;10(3):651-60.
  • Pan D, Schmieder AH, Wang K, Yang X, Senpan A, Cui G, Killgore K, Kim B, Allen JS, Zhang H, Caruthers SD, Shen B, Wickline SA, Lanza GM. Theranostics. 2014; 4(6):565-78.
  • Wu L, Luderer M, Nelson K, Swain C, Lanza GM, Pan D*: Surface passivation of carbon nanoparticles with branched macromolecules influences near infrared bio-imaging. Theranostics 2013, 3(9):677-86.
  • Schmieder AH, Wang K, Zhang H, Senpan A, Pan D, Keupp J, Caruthers SD, Wickline SA, Shen B, Wagner EM, Lanza GM. Characterization of early neovascular response to acute lung ischemia using simultaneous 19F/ 1H MR molecular imaging. Angiogenesis. 2014 Jan;17(1):51-60.
  • Pan D*, Kim B, Wang LH, Lanza GM. A Brief Account of Nanoparticle Contrast Agents for Photoacoustic Imaging. Nanomedicine and Nanobiotechnology (WIRE), 2013, 5(6):517-43.
  • Schirra CO, Roessl E, Koehler T, Brendel B, Thran A, Pan D, Anastasio MA, Proksa R.: Statistical Reconstruction of Material Decomposed Data in Spectral CT. IEEE Trans Med Imaging. 2013, 32(7):1249-57.
  • Wu L, Cai X, Zhang R, Nelson K, Shen B, Wang LV, Lanza GM, Pan D*: A green synthesis of carbon nanoparticles from honey and their use in real-time photoacoustic imaging. Nano Research 2013, 6(5): 312-325 (Cover Article, Highlighted) Cover Link: http://www.thenanoresearch.com/work_early.asp
  • Pan D* "Theranostic Nanomedicine with Functional Nanoarchitechture" Special thematic issue for Molecular Pharmaceutics 2013; 10(3):781-2. (Invited guest editor) Cover Link: http://pubs.acs.org/toc/mpohbp/10/3
  • Pan D*. Nephrogenic Systemic Fibrosis (NSF): What It Really Means for Materials Scientists? J Biotechnol Biomaterial 2012, 2, e109.
  • Schirra CO, Senpan A, Roessl E, Stacy JA, Wickline SA, Proska R, Pan D*: Second Generation Gold Nanobeacons for Robust K-Edge Imaging with Multi-Energy CT. J. Mat. Chem. 2012 22(43):23071-23077.
  • Zhou HF, Yan H, Senpan A, Wickline SA, Pan D, Lanza GM, Pham CT: Targeted lipase-labile fumagillin prodrug nanoparticles suppress inflammation in a mouse model of rheumatoid arthritis. Biomaterials 2012, 33(33): 8632-40.
  • Kim B, Schmieder AH, Stacy AJ, Williams TA, Pan D*: Sensitive Biological Detection with a Soluble and Stable Polymeric Paramagnetic Nanocluster. J Am Chem Soc. 2012, 134(25), 10377-80.
  • Pan D*, Cai X, Kim B, Senpan A, Wickline SA, Wang LV, Lanza GM: Driving Down the Particle Size of Polymeric Micelles for Extravascular Imaging and Drug Delivery. Advanced Health Materials, 2012, 1(5):582-9.
  • Kim B, Yalaz C, Pan D*: Synthesis and characterization of membrane stable bis(arylimino)isoindole dyes and their potential application in nano-biotechnology. Tetrahedron Letters, 2012, 53(32), 4134-4137.
  • Pan D*, Sanyal N, Schmieder AH, Senpan A, Kim B, Yang X, Hu G, Allen JS, Wickline SA, Lanza GM: Synthesis of Lipase-labile and Photo-chemically robust sn-2 fumagillin prodrugs for antiangiogenic therapy. Nanomedicine (UK), 2012, 7(10):1507-19.
  • Pan D*, Schirra CO, Senpan A, Schmieder AH, Roessl E, Stacy JA, Wickline SA, Proska R, Lanza GM: An Early Investigation of Ytterbium Nanocolloids for Highly Sensitive “Multi-color” Spectral CT Imaging. ACS Nano 2012, 6 (4), 3364-3370.
  • Pan D*, Cai X, Yalaz C, Senpan A, Wickline SA, Wang LV, Lanza GM: Self-assembled nanostructure from copper neodecanoate for photoacoustic detection of sentinel lymphnodes. ACS Nano 2012, 6 (2), 1260-1267.
  • Pan D*, Schmieder A, Wickline SA, Lanza GM: Manganese-based MRI contrast agents: past, present and futures. Tetrahedron 2011, 67(44), 8431-8444.
  • Pan D*, Caruthers SD, Senpan A, Schmieder AH, Wickline SA, Lanza GM: Revisiting an old friend: manganese-based MRI contrast agents. Nanomedicine and Nanobiotechnology, 2011, 3(2), 162-173.
  • Pan D*, Pramanik M, Wickline SA, Wang LH, Lanza GM: Recent Advances in Colloidal Gold Nanobeacons for Molecular Photoacoustic Imaging. Contrast Media and Molecular Imaging 2011, 6 378-388.
  • Pan D*, Caruthers SD, Senpan A, Yalaz C, Allen JS, Gaffney PJ, Wickline SA, Lanza, GM: Synthesis of NanoQ, a Copper-Based Contrast Agent, for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus. J. Am. Chem. Soc. 2011, 133(24), 9168-9171.
  • Pan D*, Pramanik M, Senpan A, Stacy A, Zhang H, Wickline SA, Wang LV, Lanza GM: Molecular photoacoustic imaging of angiogenesis with integrin targeted gold nanobeacons. Faseb J 2011, 25, 875-882. (Highlighted in science magazines)
  • Pham CTN, Mitchell LM, Huang JL, Lubniewski CM, Schall OF, Kilgore JK, Pan D, Wickline SA, Lanza GM, Hourcade DE. Variable antibody-dependent activation of complement by functionalized phospholipid nanoparticle surfaces. J Biological Chemistry 2011, 286, 123-130.
  • Pan D*, Schmieder A, Sanyal N, Yang X, Senpan A, Allen J, Zhang H, Wickline SA, Lanza G. Enhanced antiangiogenic efficacy of prodrug nanoparticles quantified with magnetic resonance imaging. J. Am. Coll. Cardiol, 2011, 57 (14), E1592.
  • Pan D*, Pramanik M, Zhang H, Senpan A, Stacy A, Wickline SA, Wang LV, Lanza GM. Photoacoustic tomography differentiates early vulnerable neoangiogenesis from mature vasculature in vivo. J. Am. Coll. Cardiol, 2011, 57 (14), E1595.
  • Pan D*, Pramanik M, Senpan A, Ghosh S, Wickline SA, Wang LV, Lanza GM: Near infrared photoacoustic detection of sentinel lymphnodes with gold nanobeacons. Biomaterials 2010, 31, 4088-4093.
  • Pan D, Caruthers SD, Chen J, Winter PM, Senpan A, Schmieder AH, Wickline SA, Lanza GM: Nanomedicine strategies for molecular targets with MR and optical imaging. Future Med. Chem. March 2010, 2(3), 471-490. (Invited review)
  • Pan D*, Rossel E, Scholmka JP, Caruthers SD, Senpan A, Scott, MJ, Zhang H, Gaffney PJ, Choi ET, Rasche V, Wickline SA, Proksa R, Lanza GM: Computed Tomography in Color: Molecular Imaging of Ruptured Atherosclerotic Plaque with Fibrin-specific Spectral CT Nanobeacons. Angew Chem Int. Ed., 2010, 49, 9635-9639. (Highlighted in science magazines)
  • Pan D*, Pramanik M, Senpan A, Wickline SA, Wang LV, Lanza GM: A facile synthesis of novel self-assembled gold nanorods designed for near-infrared imaging, J. Nanosci. Nanotech. 2010, 10, 8118-8123.
  • Lanza GM, Marsh JN, Hu G, Scott M, Schmieder AH, Caruthers SD, Pan D, Wickline SA: Rationale for a Nanomedicine Approach to Thrombolytic Therapy, Stroke 2010, S42-S44.
  • Pan D*, Pramanik M, Senpan A, Yang X, Scott, MJ, Song KH, Gaffney PJ, Wickline SA, Wang LV, Lanza GM: Molecular Photo Acoustic Imaging (PAI) with Ligand-Directed Gold Nanobeacons. Angew Chem. Int Ed. 2009, 48, 4170-4173.
  • Pan D*, Williams T, Senpan A, Allen JS, Scott MJ, Gaffney PJ, Wickline SA, Lanza, GM: Detecting Vascular Biosignatures with a Colloidal, Radio-Opaque Polymeric Nanoparticle J. Am. Chem. Soc. 2009; 131(42):15522-15527.
  • Pan D*, Caruthers SD*, Wickline SA, Lanza GM: Nanomedicine: Perspective and promises with ligand-directed molecular imaging. European J. Rodiology, 2009, 70, 274-285. (Invited review)
  • Pan D*, Senpan A, Caruthers SD, Williams T, Scott MJ, Gaffney PJ, Wickline SA, Lanza, GM: Sensitive and efficient detection of thrombus with fibrin-specific manganese nanocolloids. Chemical Communications. 2009, 22, 3234. (Highlighted as hot article)
  • Senpan A, Caruthers SD, Rhee I, Mauro NA, Pan D, Hu G, Scott MJ, Fuhrhop RW, Gaffney PJ, Wickline SA, Lanza GM. Conquering the dark side: colloidal iron oxide nanoparticles. ACS Nano. 2009;3(12), 3917-26.
  • Pan D*, Caruthers SD, Hu G, Senpan A, Scott, MJ, Gaffney PJ, Wickline SA, Lanza GM: Ligand-Directed Nanobialys as Theranostic Agent for Drug Delivery and Manganese-Based Magnetic Resonance Imaging of Vascular Targets. J. Am. Chem. Soc. 2008; 130(29):9186-7.
  • Rossin R, Pan D, Qi K, Turner JL, Welch MJ, Wooley KL: 64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: synthesis, radio labeling and biological evaluation. J Nucl. Med. 2005; 46:1210.
  • Turner JL, Pan D, Plummer R, Chen Z, Whittaker AK, Wooley KL: Synthesis of Gadolinium Labeled Shell Crosslinked Nanoparticle for Magnetic Resonance Imaging Applications. Adv. Func. Mat. 2005; 15:1248.
  • Pan D, Turner JL, Wooley KL: Shell crosslinked nanoparticles designed to target angiogenic blood vessels via avß3 receptor-ligand interactions. Macromolecules 2004; 37:7109.
  • Becker ML, Remsen EE, Pan D, Wooley KL: Peptide Derivatized Shell Cross-linked (SCK) Nanoparticles. 1) Synthesis and Characterization. Bioconjugate Chemistry 2004; 15:699. (Highlighted As Hot Article) (Cover Article)
  • Brahma S, Pan D, Ray JK: Molecular recognition: studies on the synthesis of methylene pivotal bis-thio carboxamide derivatives as ditopic receptor for suberic acid. Supramolecular Chemistry 2004; 16:447.
  • Pan D, Turner JL, Wooley KL: Folic acid conjugated nanostructured materials designed for cancer cell targeting. Chemical Communications 2003; 19:2400. (Highlighted; Cover Article)
  • Mahato TK, Pan D, Mal SK, Ray JK: Chlorine directed formylation of chloro indanones under Vilsmier-Haack reaction condition. J. Ind. Chem. Soc. 2003; 80: 969. (special commemorative issue)
  • Pan D, Kar GK, Ray JK: Indium mediated allylation of beta-chlorovinylaldehydes: a facile one-pot synthesis of 1- chlorohexa-1,5- diene-3-ol derivatives. Synthetic Communications 2003; 3:1- 9.
  • Pan D, Mal SK, Kar GK, Ray JK: Highly chemoselective method for the synthesis of 4-hydroxy-4-allylcyclohexa-2,5-dienone derivatives by indium-mediated allylation protocol. Tetrahedron 2002; 58:2847-2852.
  • Ray JK, Gupta S, Pan D, Kar GK: Molecular Recognition: Studies on the synthesis of some bis thiophenecarboxamide derivatives as ditopic receptor to long chain dicarboxylic acids. Tetrahedron 2001; 57:7213-7219.
  • Pan D, Kar GK, Ray JK, Lin JM, Amin S, Fun HK: Studies on cavity shaped polycyclic fluoro azaarenes: Synthesis of trans-9- fluoro-3,4-dihydroxy 3,4- dihydrobenz[c]acridine and trans- 11-fluoro-3,4- dihydroxy 3,4 dihydrobenz[c]acridine as potential proximate carcinogenic metabolite of fluorobenz[c]acridine. J. Chem. Soc. Perkin Trans 1 2001; 19:2470-2475.
  • Pan D, Ray JK: Regioselective alkylation of polycyclic thiophene derivatives by butyllithium and alkylhalide. Synthetic Communications 2000; 30:3569-3573.
  • Pan D, Roy BC, Kar GK, Ray JK: Highly site selective alkylation reaction of bent aza heterocycles by alkyllithium and alkyl halides. J. Chem.Soc. Perkin Trans 1, 2000; 2171-2173.

Patents

  • US9095601 (2015) Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids ("PNAs") with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer
  • Blood Substitute Composition and Method of Use. WO 2014179793 (2014) (047563-474897).
  • “Prodrug compositions, prodrug nanoparticles, and methods of use thereof” (2011) WO 2011130674 and US 2010-324464P. (Licensed to Kereos, Inc., St. Louis, MO, USA)
  • “Ligand directed toroidal nanoparticles for therapy and diagnostic imaging” (2009) WO 2009049089 and US 20100297007
  • “Metal particles for imaging” (2009) US 20100297019 and WO 2009049083. (Licensed to Ocean Nanotech, Inc., Arkansas, USA)
  • US8354093 B2 (2013), “Cell permeable nanoconjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids ("PNAs") with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer.”

Magazine Articles

Honors

  • Management Award, GE Global Research, JFWTC (2006)
  • Fellow, Royal Society of Chemistry (UK) (2014)
  • Fellow, American Heart Association (2016)
  • Fellow, American College of Cardiology (2017)

Teaching Honors

  • Lists of Teachers Ranked as Excellent, BIOE 598, UIUC (2016)

Research Honors

  • Career Award (Scientist Development Grant), American Heart Association (2008)
  • Innovative Research Award, American Heart Association (2011)
  • Engineering Council Outstanding Advisor Award (2015)